Anti-CLDN5 antibodies are used in the immunodetection of the protein claudin 5. In humans, the canonical protein has a reported length of 218 amino acid residues and a mass of 23.1 kDa. Its subcellular localization is in the cell membrane. It is notably widely expressed in many tissue types. A member of the Claudin protein family, Cldn5 is known to play an important role in tight junction-specific obliteration of the intercellular space. The CLDN5 marker can be used to identify Retinal Blood Vessel Endothelial Cells, Endothelial Cells, Aerocyte Capillary (aCap) Cells, Cap1 General Capillary (cGap) Cells, and Respiratory Vein Endothelial Cells.* Synonyms for this target antigen include BEC1, TMDVCF, TMVCF, transmembrane protein deleted in VCFS, and AWAL. CLDN5 gene orthologs have been reported in the mouse, rat, bovine, frog, zebrafish, chimpanzee and chicken species.
*HuBMAP Human Reference Atlas v1.4