Caspases, a family of intracellular cysteine proteases, are enzymes critical to several cellular functions including apoptosis and inflammation. Apoptosis is the process by which cells program their own death, a process critical for maintaining homeostasis within all living organisms. It has been shown that unregulated apoptosis is associated with several diseases including cancer and autoimmune disorders. A system with abnormal apoptosis function can experience an accumulation of excess cells, potentially leading to tumor formation and uncontrolled inflammation. Since caspases are responsible for correct apoptotic function, caspase inhibitors are being widely investigated as potential drug therapies for cancer and other diseases.
Considerations for selecting the best assay for your applications
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From 4D proteomics to artificial intelligence
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Set up a live demo with a Bio-Rad Imaging Specialist - Request a DemoUse the ChemiDoc MP Imaging System for flexible, high-sensitivity multiplex fluorescent and chemiluminescence western blot detection, imaging gels, analysis and documentation. This ...
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The Sapphire FL Biomolecular Imager is a field-upgradable laser scanner, with a wide selection of user-adjustable lasers and filters. It features 5-micron resolution, adjustable Z-plane focus and a wide field of view of 25cm X 25cm. Applications ...
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Caspases are cysteine-dependent, aspartate-specific proteases, which play essential roles in apoptosis and are also required in the immune system for the maturation of cytokines (such as IL-1 and IL-18). They exist as latent...
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In our cell culture, Trypsin inhibitors are used in cell culture experiments to further inhibit tryptic activity during cell dissociation to prevent cell damage/death.
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