Caspase-8 is a cysteine protease known for its roles in Fas-induced apoptosis and lymphocyte activation. Activation of caspase-8 is an initiator for several other members of the caspase family and can lead to downstream mitochondrial damage. Caspase-8 inhibitors are being explored for their potential therapeutic roles in neurodegenerative diseases and cancer. Compare caspase-8 inhibitor listings below.