The Biocompare Inhibitor Search Tool lets researchers browse thousands of compounds by searching by inhibitor name or by its target enzyme. Simply search by “Keywords” if you know the name of the inhibitor, or search by “Inhibitor Target” to enter the name of your protein of interest. Additionally, you may check the appropriate boxes to narrow down your search.
Caspase-2 is a cysteine protease that plays a key role in apoptosis, but appears to have multiple functions beyond cell death. Many aspects of caspase-2 activation and function remain unclear, but it appears that it acts both as an activator and inhibitor of apoptosis. Caspase-2 inhibitors are vital to studies to better understand the role caspase-2 plays in various disease states and are being studied as potential therapeutic targets for disorders involving apoptosis such as Alzheimer’s and Huntington’s. The fluor-methyl peptide inhibitor, VDVAD-FMK, is one of the most well-known capsase-2 inhibitors but several other peptide and small molecule inhibitors are available for this target.