Apoptosis Inhibitors

Apoptosis is a carefully controlled program with pathways that involve an assortment of proteins with varying forms and functions. In studying or manipulating these proteins, inhibitors have become well-established tools. For instance, several peptide inhibitors have been developed to block specific or pan- caspases, the terminal apoptotic enzymes responsible for the proteolysis of cellular organelles. The Bcl-2 family of proteins, which either prevent or promote apoptotic signaling, have also become subject to several drug candidates, such as ABT-737 and ABT-263. If seeking inhibitors for other targets, just visit any inhibitor page and enter a new protein name or inhibitor in the provided search box.