Anti-MIP antibodies are used in the immunodetection of the protein major intrinsic protein of lens fiber. In humans, the canonical protein has a reported length of 263 amino acid residues and a mass of 28.1 kDa. Its subcellular localization is in the cell membrane. It is reported to be expressed in the cortex and nucleus of the retina lens. A member of the MIP/aquaporin (TC 1.A.8) protein family, MIP is known to be involved with eye development. Post-translational modifications have been described, including palmitoylation and protein cleavage. The MIP gene has been associated with the disease, Cataracts. Synonyms for this target antigen include CTRCT15, LIM1, MIP26, MP26, lens fiber major intrinsic protein, aquaporin 0, and AQP0. MIP gene orthologs have been reported in the mouse, rat, bovine, frog, zebrafish, chimpanzee and chicken species. A number of MIP antibodies have been mentioned in research publications and have associated citations. Immunohistochemistry is a widely used application for these antibodies. ELISA and Western Blot are also common applications.