Anti-SATB2 antibodies are used in the immunodetection of the protein SATB homeobox 2. In humans, the canonical protein has a reported length of 733 amino acid residues and a mass of 82.6 kDa. Its subcellular localization is in the nucleus. Up to 2 different isoforms have been reported for this protein. It is notably expressed in the small intestine, rectum, colon, cerebral cortex, and appendix. A member of the CUT homeobox protein family, SATB2 is known to bind to DNA, at nuclear matrix- or scaffold-associated regions. Post-translational modifications have been described, including sumoylation.
The SATB2 marker can be used to identify Proximal Tubule Segment 3 Epithelial Cells, Descending Thin Limb Cells, Type 1 Descending Thin Limb Cells, and Medial Excitatory Neurons.* Synonyms for this target antigen include DEL2Q32Q33, GLSS, DNA-binding protein SATB2, SATB family member 2, SATB2 fusion, and C2DELq32q33. SATB2 gene orthologs have been reported in the mouse, rat, bovine, frog, zebrafish, chimpanzee and chicken species. Over 70 citations in the literature describe the use of SATB2 antibodies in research. Immunohistochemistry is a widely used application for these antibodies. Western Blot, Immunocytochemistry, and Immunofluorescence are also common applications.
*HuBMAP Human Reference Atlas v1.4