Anti-DDB2 antibodies are used in the immunodetection of the protein damage specific DNA binding protein 2. In humans, the canonical protein has a reported length of 427 amino acid residues and a mass of 47.9 kDa. Its subcellular localization is in the nucleus. Up to 5 different isoforms have been reported for this protein. It is notably widely expressed in many tissue types. A member of the WD repeat DDB2/WDR76 protein family, DDB2 is known to be involved with DNA damage pathways and DNA repair.
The DDB2 marker can be used to identify Granular Keratinocytes and Basal Keratinocytes.* Synonyms for this target antigen include UV-DDB2, XPE, DNA damage-binding protein 2, DDB p48 subunit, UV-damaged DNA-binding protein 2, and DDBB. DDB2 gene orthologs have been reported in the mouse, rat, bovine, frog, zebrafish, chimpanzee and chicken species. Over 70 citations in the literature describe the use of DDB2 antibodies in research. Western Blot is a widely used application for these antibodies. Immunofluorescence and Immunohistochemistry are also common applications.
*HuBMAP Human Reference Atlas v1.4