This video explores the challenge of growing anchorage-dependent cells, which must attach to surfaces like tissue culture flasks to proliferate. When producing these cells at an industrial scale, the required surface area becomes too large for traditional vessels.
The solution? Microcarriers—tiny beads suspended in liquid culture that provide vast surface area for cell growth inside bioreactors. Microcarriers are essential in manufacturing cutting-edge therapies such as viral vaccines and stem cell-derived exosomes, but not every microcarrier performs equally.
Traditional microcarriers face significant obstacles during scale-up: they expose cells to damaging shear stress and restrict how densely cells can grow, limiting productivity. Asahi Kasai Corporation addresses these issues with BioCradle™ microcarriers—cellulose beads featuring a unique macroporous structure and positive charges throughout their matrix.
This design protects cells from shear damage, supports higher cell densities per bead, and maintains cell viability even under intensive bioreactor conditions. Available in two grades with different charge capacities, BioCradle™ microcarriers have demonstrated markedly higher cell yields compared to other commercial products over a seven-day culture period.
Their innovative structure offers a scalable approach for efficient adherent cell production, overcoming limitations of traditional methods. For those interested in scaling up adherent cell culture for research or industrial biomanufacturing, this video presents a concise and insightful overview of how microcarrier technology, especially BioCradle™ microcarriers, can enhance outcomes and efficiency.
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