Anti-CD226 antibodies are used in the immunodetection of the protein CD226 molecule. In humans, the canonical protein has a reported length of 336 amino acid residues and a mass of 38.6 kDa. Its subcellular localization is in the cell membrane. It is noted to be expressed by peripheral blood T-lymphocytes. CD226 is known to be involved in intercellular adhesion, lymphocyte signaling, cytotoxicity and lymphokine secretion mediated by cytotoxic T-lymphocyte (CTL) and NK cell. Post-translational modifications have been described, including glycosylation.
The CD226 marker can be used to identify Thalamic Excitatory Neurons.* Synonyms for this target antigen include DNAM1, PTA1, TLiSA1, CD226 antigen, DNAX accessory molecule-1, and DNAM-1. CD226 gene orthologs have been reported in the mouse, rat, bovine, zebrafish, chimpanzee and chicken species. Over 320 citations in the literature describe the use of CD226 antibodies in research. Flow Cytometry is a widely used application for these antibodies. In addition, Western Blot is also a common application.
*HuBMAP Human Reference Atlas v1.4