What are CD122 antibodies?
Anti-CD122 antibodies are immunoglobulins that specifically recognize and bind CD122, encoded by the IL2RB gene in humans. In research applications, these antibodies are used to detect CD122 in tissue samples, cell lysates, and cultured cells. CD122 is the beta subunit of the interleukin-2 receptor that mediates receptor-mediated endocytosis and transduces the mitogenic signals of IL-2, and it also participates in IL-15-driven stimulation of neutrophil phagocytosis. Because CD122 shapes lymphocyte proliferation and effector function, it is studied extensively in immunology and cancer immunotherapy research.
Catalog highlights and purchasing considerations
About the Biocompare CD122 antibody catalog
The Biocompare antibody search tool lists CD122 antibodies from a limited number of suppliers, with western blot, ELISA, and immunohistochemistry among the most common validated applications. Listings may also appear under the gene symbol IL2RB or the alternate designation IL-2R beta, along with phospho-specific variants targeting a regulatory tyrosine residue.
Considerations when choosing a CD122 antibody for research
Confirm that the antibody's intended target is accurate, as many genes carry synonym symbols that can create ambiguity across suppliers. Specificity should be verified against the immunogen sequence or region listed on the product datasheet, since antibodies raised against different epitopes of the same protein can behave differently across applications. Beyond specificity, several target-related attributes can affect antibody binding, including subcellular location, extracellular and cytoplasmic domain boundaries for membrane-associated targets, tissue specificity, post-translational modifications, and the presence of additional isoforms or disease-associated variants. In parallel, antibody-specific selection criteria warrant consideration, including clonality (monoclonal versus polyclonal), host species, species reactivity, and conjugate or label choice suited to the detection method. Supplier validation data, such as western blot bands at the expected molecular weight, immunohistochemistry staining patterns consistent with known tissue distribution, and knockout or knockdown controls, should also be carefully reviewed before purchase.