Anti-Sequestosome-1 antibodies are used for the immunodetection of the protein encoded by the SQSTM1 gene. In humans, the canonical protein has a reported length of 440 amino acid residues and a mass of 47.7 kDa. Its subcellular localization is in the nucleus, cytoplasmic vesicles, ER, lysosomes and cytoplasm. Alternative splicing is reported to yield 2 different isoforms for this protein. It is ubiquitously expressed across many tissue types. It is known to be an autophagy receptor required for selective macroautophagy (aggrephagy). Post-translational modifications have been described, including ubiquitination, protein cleavage and phosphorylation. Other names for this target antigen include A170 and DMRV. Gene orthologs have been identified in the mouse, rat, bovine, frog, zebrafish, chimpanzee and chicken species. A number of Sequestosome-1 antibodies have been mentioned in research publications and have associated citations. Western Blot is a widely used application for these antibodies. ELISA, Immunofluorescence, and Immunohistochemistry are also common applications.