Anti-PDGFB antibodies are used in the immunodetection of the protein platelet derived growth factor subunit B. In humans, the canonical protein has a reported length of 241 amino acid residues and a mass of 27.3 kDa. It has been described to be a secreted protein. It is notably expressed at high levels in the heart, brain (sustantia nigra), placenta and fetal kidney. A member of the PDGF/VEGF growth factor protein family, PDGFB is reported to be a growth factor that plays an essential role in the regulation of embryonic development, cell proliferation, cell migration, survival and chemotaxis. Post-translational modifications have been described, including glycosylation. The PDGFB gene has been associated with the disease, Basal ganglia calcification. Synonyms for this target antigen include PDGF-2, PDGF2, SIS, SSV, c-sis, PDGF subunit B, PDGF, B chain, and IBGC5. PDGFB gene orthologs have been reported in the mouse, rat, bovine, frog, chimpanzee and chicken species.