Anti-Endoglin antibodies are used for the immunodetection of the protein encoded by the ENG gene. In humans, the canonical protein has a reported length of 658 amino acid residues and a mass of 70.6 kDa. Its subcellular localization is in the cell membrane. Alternative splicing is reported to yield 2 different isoforms for this protein. It is noted to be involved in bone development and cell adhesion. Post-translational modifications have been described, including glycosylation. The gene encoding this protein is implicated in Telangiectasia. Other names for this target antigen include HHT1, ORW1, CD105 antigen, soluble endoglin, and END. Gene orthologs have been identified in the mouse, rat, bovine, frog, chimpanzee and chicken species.