Anti-CASP5 antibodies are used in the immunodetection of the protein caspase 5. In humans, the canonical protein has a reported length of 434 amino acid residues and a mass of 49.7 kDa. It is reported to be expressed in barely detectable amounts in most tissues except brain, highest levels being found in the lung, liver and skeletal muscle. A member of the Peptidase C14A protein family, CASP5 is reported to be a thiol protease that acts as a mediator of programmed cell death. Synonyms for this target antigen include ICEREL-III, ICH-3, TY protease, caspase 5, apoptosis-related cysteine peptidase, caspase 5, apoptosis-related cysteine protease, and ICE(rel)III. CASP5 gene orthologs have been reported in the mouse, rat and chimpanzee species. A number of CASP5 antibodies have been mentioned in research publications and have associated citations. Western Blot is a widely used application for these antibodies. ELISA, Immunocytochemistry, Immunofluorescence, and Immunohistochemistry are also common applications.