Description
Gasdermin D (E8G3F) Rabbit mAb recognizes endogenous levels of total Gasdermin D protein. This antibody recognizes the 30 kDa amino terminal fragment produced during pyroptosis by caspase-1, a 43 kDa fragment produced by caspase-3, as well as a 21 kDa fragment produced by cleavage at both sites. Cleaved Gasdermin D (Asp275) (E7H9G) Rabbit mAb detects the N-terminal fragment of human Gasdermin D protein only when cleaved at Asp275. Caspase-1 (D7F10) Rabbit mAb detects endogenous levels of full length human caspase-1 and the activated p20 subunit by overexpression. Cleaved Caspase-1 (Asp297) (D57A2) Rabbit mAb detects the p20 subunit of human caspase-1 upon cleavage at Asp275. IL-1β (D3U3E) Rabbit mAb can recognize endogenous levels of full-length protein, but does not detect endogenous levels of the mature IL-1β. It can detect up to 100 pg of recombinant mature IL-1β. Cleaved IL-1β (Asp116) (D3A3Z) Rabbit mAb detects endogenous levels of mature IL-1β protein when cleaved at Asp116. Caspase-4 Antibody detects endogenous levels of total caspase-4 and intermediate forms at 40 and 32 kDa. Caspase-5 (D3G4W) Rabbit mAb detects endogenous levels of caspase-5. HMGB1 (D3E5) Rabbit mAb detects endogenous levels of total HMGB1. It does not cross-react with other HMGB proteins, including HMGB2 and HMGB3