Anti-Cullin 2 antibodies are used for the immunodetection of the protein encoded by the CUL2 gene. In humans, the canonical protein has a reported length of 745 amino acid residues and a mass of 87 kDa. Its subcellular localization is in the nucleus. Alternative splicing is reported to yield 2 different isoforms for this protein. A member of the Cullin protein family, it is an important component of multiple cullin-RING-based ECS (ElonginB/C-CUL2/5-SOCS-box protein) E3 ubiquitin-protein ligase complexes, which mediate the ubiquitination of target proteins. Post-translational modifications have been described, including ubiquitination. Other names for this target antigen include testis secretory sperm-binding protein Li 238E. Gene orthologs have been identified in the mouse, rat, bovine, frog, zebrafish, chimpanzee and chicken species. Over 80 citations in the literature describe the use of Cullin 2 antibodies in research. Western Blot is a widely used application for these antibodies. ELISA, Immunofluorescence, and Immunohistochemistry are also common applications.