Anti-ACTA1 antibodies are used in the immunodetection of the protein actin alpha 1, skeletal muscle. In humans, the canonical protein has a reported length of 377 amino acid residues and a mass of 42.1 kDa. Its subcellular localization is in the cytoplasm. It is notably expressed in many tissues, such as the appendix and colon. A member of the Actin protein family, ACTA1 is known to be involved with the regulation of gene expression. Post-translational modifications have been described, including methylation, acetylation and protein cleavage. The ACTA1 marker can be used to identify Myo-Medullary Thymic Epithelial Cells.* Synonyms for this target antigen include ASMA, CFTD, CFTD1, CFTDM, CMYP2A, CMYP2B, CMYP2C, and ACTA. ACTA1 gene orthologs have been reported in the mouse, rat, bovine, chimpanzee and chicken species.
*HuBMAP Human Reference Atlas v1.4