Anti-MET antibodies are used in the immunodetection of the protein MET proto-oncogene, receptor tyrosine kinase. In humans, the canonical protein has a reported length of 1390 amino acid residues and a mass of 155.5 kDa. Its subcellular localization is in the membrane and is secreted. Up to 3 different isoforms have been reported for this protein. It is reported to be expressed in normal hepatocytes as well as in epithelial cells lining the stomach, the small and the large intestine. A member of the Tyr protein kinase protein family, MET is a known receptor tyrosine kinase that transduces signals from the extracellular matrix into the cytoplasm by binding to hepatocyte growth factor/HGF ligand.
The MET marker can be used to identify Cerebral Cortex Chandelier Neurons.* Synonyms for this target antigen include DA11, DFNB97, HGFR, RCCP2, c-Met, hepatocyte growth factor receptor, HGF receptor, and AUTS9. MET gene orthologs have been reported in the mouse, rat, bovine, frog, zebrafish, chimpanzee and chicken species. Over 1700 citations in the literature describe the use of MET antibodies in research. Western Blot is a widely used application for these antibodies. In addition, ELISA is also a common application.
*HuBMAP Human Reference Atlas v1.4