Anti-SIGLEC8 antibodies are used in the immunodetection of the protein sialic acid binding Ig like lectin 8. In humans, the canonical protein has a reported length of 499 amino acid residues and a mass of 54 kDa. Its subcellular localization is in the membrane. Up to 3 different isoforms have been reported for this protein. It is noted to be expressed specifically on red blood cells namely basophil, mast cells and eosinophils. A member of the SIGLEC (sialic acid binding Ig-like lectin) protein family, SIGLEC8 is believed to be an adhesion molecule that mediates sialic-acid dependent binding to red blood cells. Post-translational modifications have been described, including glycosylation. Synonyms for this target antigen include SIGLEC8L, CDw329, SAF-2, sialoadhesin family member 2, and SAF2. SIGLEC8 gene orthologs have been reported in the mouse and bovine species. Over 170 citations in the literature describe the use of SIGLEC8 antibodies in research. Western Blot is a widely used application for these antibodies. ELISA and Flow Cytometry are also common applications.