Anti-TSC2 antibodies are used in the immunodetection of the protein TSC complex subunit 2. In humans, the canonical protein has a reported length of 1807 amino acid residues and a mass of 200.6 kDa. Its subcellular localization is in the membrane and cytoplasm. Up to 8 different isoforms have been reported for this protein. It is notably expressed in many tissues, such as the caudate, thyroid gland, and adrenal gland. TSC2 is reported to be in complex with TSC1, this tumor suppressor inhibits the nutrient-mediated or growth factor-stimulated phosphorylation of S6K1 and EIF4EBP1 by negatively regulating mTORC1 signaling. Synonyms for this target antigen include PPP1R160, TSC4, tuberin, protein phosphatase 1, regulatory subunit 160, tuberous sclerosis 2 protein, and LAM. TSC2 gene orthologs have been reported in the mouse, rat, bovine, frog, zebrafish, chimpanzee and chicken species. Over 680 citations in the literature describe the use of TSC2 antibodies in research. Western Blot is a widely used application for these antibodies. ELISA, Immunofluorescence, and Immunohistochemistry are also common applications.