Anti-XRCC5 antibodies are used in the immunodetection of the protein X-ray repair cross complementing 5. In humans, the canonical protein has a reported length of 732 amino acid residues and a mass of 82.7 kDa. Its subcellular localization is in the nucleus. It is notably widely expressed in many tissue types. A member of the Ku80 protein family, XRCC5 is known to be involved with brain development and DNA damage pathways. Post-translational modifications have been described, including ubiquitination, sumoylation and phosphorylation. Synonyms for this target antigen include KARP1, KU80, KUB2, Ku86, NFIV, X-ray repair cross-complementing protein 5, 86 kDa subunit of Ku antigen, and KARP-1. XRCC5 gene orthologs have been reported in the mouse, rat, bovine, frog, zebrafish, chimpanzee and chicken species. Over 370 citations in the literature describe the use of XRCC5 antibodies in research. Western Blot is a widely used application for these antibodies. ELISA, Immunocytochemistry, Immunofluorescence, and Immunohistochemistry are also common applications.