Anti-Ku80 antibody [EPR3468] ab80592 from Abcam

Product Specs
ItemAnti-Ku80 antibody [EPR3468]
CompanyAbcam
Price Supplier Page View Company Product Page
Catalog Numberab80592
Antibody TypePrimary
ClonalityMonoclonal
CloneEPR3468
ApplicationsFlow Cytometry, Immunocytochemistry/ Immunofluorescence, Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections), Immunoprecipitation, Western blot, Flow Cytometry, Immunocytochemistry/ Immunofluorescence, Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections), Immunoprecipitation, Western blot, Flow Cytometry, Immunocytochemistry/ Immunofluorescence, Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections), Immunoprecipitation, Western blot
Conjugate/TagUnconjugated
IsotypeIgG
HostRabbit
Quantity10 UL, 40 UL, 100 UL
Gene NameXRCC5
ReactivityHuman, Mouse, Rat
TargetKu80

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Abcam

Discovery Drive

Cambridge Biomedical Campus

Cambridge CB2 0AX

United Kingdom

Phone: +44 (0) 1223 696000 (option 1)
+44 (0) 1223 696000 (option 2)
+44 (0) 1223 771600

Company Profile

Website: http://www.abcam.com

(1) CRISPR generation of CSF1R-G795A human microglia for robust microglia replacement in a chimeric mouse modelSTAR ProtocolsSeptember 1, 2023Jean Paul Chadarevian, Hayk Davtyan, Sonia I. Lombroso, F. Chris Bennett, Mathew Blurton-Jonessections were labeled with goat anti-IBA1 (1:200; Abcam; ab5076) and rabbit anti-Ku80 (1:100; Abcam; ab80592) diluted in 1× PBS and 1% donkey serum and incubated overnight on a shaker at 4°C. After washing, sections

(2) Inactivating TDP2 missense mutation in siblings with congenital abnormalities reminiscent of fanconi anemiaHum GenetAugust 10, 2023Guido Zagnoli-Vieira, Jan Brazina, Kris Van Den Bogaert, Wim Huybrechts, Guy Molenaers, Keith W. Caldecott, Hilde Van EschKU80 was detected as a loading control using an anti-Ku80 rabbit monoclonal primary antibody (Abcam Ab80592). For overexpressed mCherry-tagged TDP2, anti-mCherry antibody (Abcam ab167453) was employed. Tyrosyl

(3) Using brain cell-type-specific protein interactomes to interpret neurodevelopmental genetic signals in schizophreniaiScienceMay 19, 2023Hsu YH, Pintacuda G, Liu R, Nacu E, Kim A, Tsafou K, Petrossian N, Crotty W, Suh JM, Riseman J, et al.,Cell Signaling Technology,Cat# 5539;RRID: AB_10694401 TCF4,GeneTex,Cat# GTX17912;RRID: AB_2887569 XRCC5,Abcam,Cat# ab80592;RRID: AB_1603758 XRCC6,Abcam,Cat# ab92450;RRID: AB_10562280 V5 tag,MBL,Cat# M167-11 Mouse IgG1 monoclonal

(4) Synthetic Retinoid Kills Drug-Resistant Cancer Stem Cells via Inducing RARγ-Translocation-Mediated Tension Reduction and Chromatin DecondensationAdvanced science (Weinheim, Baden-Wurttemberg, Germany)November 1, 2022Zhang Y, Dong Q, An Q, Zhang C, Mohagheghian E, Niu B, Qi F, Wei F, Chen S, Chen X, et al.#13969), H3K9ac (CST, 1:400, #9649), RAR gamma (Abcam, 1:1000, ab191368), and KU80 (Abcam, 1:1000, ab80592) antibodies in blocking solution overnight at 4 °C. Then, cells were washed in PBS and incubated with

(5) Determining the Potential of DNA Damage Response (DDR) Inhibitors in Cervical Cancer TherapyCancers (Basel)September 1, 2022Santu Saha, Stuart Rundle, Ioannis C. Kotsopoulos, Jacob Begbie, Rachel Howarth, Isabel Y. Pappworth, Asima Mukhopadhyay, Ali Kucukmetin, Kevin J. Marchbank, Nicola Curtin(Santa Cruz, Sc8408; 1:500), DNA-PKcs (Santa Cruz, Sc390849; 1:500), Ku70 (Abcam, Ab3114; 1:500), Ku80 (Abcam, Ab80592; 1:500), PARP1 (Biovision, 3001-100; 1:500), WEE1 (Santa-Cruz, 5285 1:500). ATR, CHK1 and WEE1 activity

(6) The Role of ATR Inhibitors in Ovarian Cancer: Investigating Predictive Biomarkers of ResponseCellsAugust 1, 2022Alice Bradbury, Frank T. Zenke, Nicola J. Curtin, Yvette Drew1:500), DNA-PKcs (Santa Cruz, Sc390849; 1:500), Ku70 (Abcam, Cambridge, UK, Ab3114; 1:500), Ku80 (Abcam, Ab80592; 1:500), RAD51 (Santa Cruz, Sc8349; 1:1000), PARP1 (Biovision, Milpitas, CA, USA, 3001-100; 1:500),

(7) Placenta-Derived Mesenchymal-like Adherent Stromal Cells as an Effective Cell Therapy for Cocaine Addiction in a Rat ModelPharmaceuticsJune 21, 2022Hilla Pe’er-Nissan et al.treated with blocking solution (1 h), and then incubated overnight with rabbit anti-Ku80 (1:250; Abcam, # ab80592) as a primary antibody for PLX-PAD cells. Slices were then incubated with secondary antibody (1:200

(8) Transplantation of Human Glial Progenitors to Immunodeficient Neonatal Mice with Amyotrophic Lateral Sclerosis (SOD1/rag2)Antioxidants (Basel)May 26, 2022Luiza Stanaszek, Piotr Rogujski, Katarzyna Drela, Michal Fiedorowicz, Piotr Walczak, Barbara Lukomska, Miroslaw JanowskiGermany; 1:200), rabbit anti-NuMa (#3888S, Cell Signalling, Danvers, MA, USA; 1:100), rabbit anti-Ku80 (ab80592, Abcam, Cambridge, UK; 1:200), mouse anti-STEM121 (#Y40410, Takara Bio, Kusatsa, Japan; 1:100), mouse

(9) A Surgical Kit for Stem Cell-Derived Retinal Pigment Epithelium Transplants: Collection, Transportation, and Subretinal DeliveryFrontiers in Cell and Developmental BiologyFebruary 18, 2022Kang V. Li, Miguel Flores-Bellver, Silvia Aparicio-Domingo, Carson Petrash, Hannah Cobb, Conan Chen, M. Valeria Canto-Soler, Marc T. Mathiascollected and processed for immunofluorescent labeling with anti-Ku80 antibody (rabbit anti-human, 1:200, ab80592, Abcam), and melanosome antibody (mouse anti-human, 1:200, HMB45, Dako). DAPI (4′,6-diamidino-2-phenylindole)

(10) Intravenous transplantation of amnion-derived mesenchymal stem cells promotes functional recovery and alleviates intestinal dysfunction after spinal cord injuryPloS oneJanuary 1, 2022Takamiya S, Kawabori M, Yamazaki K, Yamaguchi S, Tanimori A, Yamamoto K, Ohnishi S, Seki T, Konno K, Tha KK, et al.further confirmed by immunohistochemistry by investigating positive cells of anti-Ku80 antibody (1:500, ab80592; Abcam, Cambridge, UK) in the spinal cord, lungs, liver, and ileum. Neurological, histopathological,

(11) Co-grafts of Human Embryonic Stem Cell Derived Retina Organoids and Retinal Pigment Epithelium for Retinal Reconstruction in Immunodeficient Retinal Degenerate Royal College of Surgeons RatsFrontiers in NeuroscienceOctober 26, 2021Biju B. Thomas, Bin Lin, Juan Carlos Martinez-Camarillo, Danhong Zhu, Bryce T. McLelland, Gabriel Nistor, Hans S. Keirstead, Mark S. Humayun, Magdalene J. SeilerActon, MA, United States)",70R-19908,N/A Ku80,Rabbit,Human nuclei,1:400 (fl. Ab) 1:2K (ABC),Abcam,ab80592,AB_1603758 PKCα,Mouse,Rod bipolar cells,1:200 (fl. Ab),Stressgen,KAM-PK020,AB_1193543 Recoverin,Rabbit,"Photoreceptors,

(12) Proximity Ligation Assay Detection of Protein-DNA Interactions-Is There a Link between Heme Oxygenase-1 and G-quadruplexes?Antioxidants (Basel, Switzerland)January 12, 2021Krzeptowski W, Chudy P, Sokołowski G, Żukowska M, Kusienicka A, Seretny A, Kalita A, Czmoczek A, Gubała J, Baran S, et al.Villeurbanne, France), anti-KU70 (#sc-1487, Santa Cruz Biotechnology, Dallas, TX, USA), anti-KU80 (#ab80592, Abcam, Cambridge, UK), and anti-PIF1 (#PA5-37136, Invitrogen). 2.6. Fluorescence-Activated Cell Sorting

(13) HOXB7 mediates cisplatin resistance in esophageal squamous cell carcinoma through involvement of DNA damage repairThoracic CancerNovember 1, 2020Ting Zhou, Hao Fu, Bin Dong, Liang Dai, Yongbo Yang, Wanpu Yan, Luyan Shenimmunoreacted with anti‐HOXB7 (Abcam, ab51237 at 1:50), anti‐Ku70 (Abcam, ab92450 at 1:1000), anti‐Ku80 (Abcam, ab80592 at 1:1000), anti‐DNA‐PKcs (CST, #5591 at 1:1000), anti‐γ‐H2AX (CST, #9718 at 1:1000) and anti‐GAPDH

(14) Retina Organoid Transplants Develop Photoreceptors and Improve Visual Function in RCS Rats With RPE DysfunctionInvestigative Opthalmology & Visual ScienceSeptember 18, 2020Bin Lin, Bryce T. McLelland, Robert B. Aramant, Biju B. Thomas, Gabriel Nistor, Hans S. Keirstead, Magdalene J. SeilerMedical (Pacheco, CA)",901-290-031218,N/A Ku80,Rabbit,Human nuclei,1:400 (fl. Ab)1:2K (ABC),Abcam,ab80592,AB_1603758 MAP2,Mouse,Ganglion cells,1:200 (fl.Ab),Millipore,MAB3418,AB_94856 Otx2,Rabbit,Homeobox

(15) Mitochondrial APE1 promotes cisplatin resistance by downregulating ROS in osteosarcomaOncology ReportsJune 4, 2020Yufeng Liu, Zhimin Zhang, Qing Li, Liang Zhang, Yi Cheng, Zhaoyang Zhongno. 17774, dilution 1:5,000; Santa Cruz Biotechnology, Inc.); anti-ku80 (rabbit monoclonal, cat. no. ab80592, dilution 1:3,000; Abcam); anti-tubulin (rabbit monoclonal, cat. no. 2128, dilution 1:1,000; Cell Signaling Technology

(16) Effects of ASC Application on Endplate Regeneration Upon Glycerol-Induced Muscle DamageFrontiers in molecular neuroscienceJanuary 1, 2020Rigon M, Hörner SJ, Straka T, Bieback K, Gretz N, Hafner M, Rudolf R.antibody,Rockland,600-401-103-0.1,40681,1:500 Recombinant anti-Ku80 antibody (EPR3468),Abcam,GR3216586-3,ab80592,1:300 Secondary antibody/marked toxins/dyes,Secondary antibody/marked toxins/dyes,Secondary antibody/marked

(17) The interactome of the prostate-specific protein Anoctamin 7Cancer biomarkers : section A of Disease markersJanuary 1, 2020Kaikkonen E, Takala A, Pursiheimo JP, Wahlström G, Schleutker J.anti-HSPA1A (ab79852), anti-AP2B1 (ab220778), anti-SND1 (Abcam ab65078, Boston, USA), anti-XRCC5 (Abcam ab80592, Boston, USA), anti-6 × His tag (Abcam ab18184), anti-HA tag (Abcam ab130275), (Abcam, Boston, USA),

(18) A nucleotide resolution map of Top2-linked DNA breaks in the yeast and human genomeNature CommunicationsDecember 1, 2019William H. Gittens, Dominic J. Johnson, Rachal M. Allison, Tim J. Cooper, Holly Thomas, Matthew J. Nealeat 4 °C with antibodies targeting TOP2β (Clone 40, BD Biosciences), TOP2α (ab52934, Abcam), or Ku80 (ab80592, Abcam), all at 1/1000 dilution. Secondary immunodetection was by incubation for 1 h at room temperature

(19) PLK1 facilitates chromosome biorientation by suppressing centromere disintegration driven by BLM-mediated unwinding and spindle pullingNature communicationsJune 28, 2019Addis Jones O, Tiwari A, Olukoga T, Herbert A, Chan KL.1:2000), anti-PICH (Abnova; H00054821-B01P, 1:300), anti-GFP (Abcam, ab290, 1:1000) and anti-Ku80 (Abcam, ab80592, 1:10000). All uncropped blot scans are available in the Supplementary excel data file. Flow cytometry Cells

(20) 53BP1 can limit sister-chromatid rupture and rearrangements driven by a distinct ultrafine DNA bridging-breakage processNature CommunicationsDecember 1, 2018Ankana Tiwari, Owen Addis Jones, Kok-Lung Chanstudy: anti-53BP1 (Abcam, ab36823; 1:7000), anti-53BP1 (Santa Cruz, H-300; 1:800), anti-Ku80 (Abcam, ab80592; 1:10000) and anti-β-actin (Sigma, A5316; 1:5000). Secondary antibodies used: goat anti-rabbit HRP (Amersham

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Anti-Ku80 antibody [EPR3468] from Abcam

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Anti-Ku80 antibody [EPR3468] from Abcam

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