Anti-TXN antibodies are used in the immunodetection of the protein thioredoxin. In humans, the canonical protein has a reported length of 105 amino acid residues and a mass of 11.7 kDa. Its subcellular localization is in the nucleus, cytoplasm, and is secreted. Up to 2 different isoforms have been reported for this protein. It is notably widely expressed in many tissue types. A member of the Thioredoxin protein family, TXN is reported to participate in various redox reactions through the reversible oxidation of its active center dithiol to a disulfide and catalyzes dithiol-disulfide exchange reactions. Synonyms for this target antigen include TRX, TRX1, Trx80, ADF, ATL-derived factor, SASP, TXN delta 3, and TRDX. TXN gene orthologs have been reported in the mouse, bovine, chimpanzee and chicken species. Over 180 citations in the literature describe the use of TXN antibodies in research. Western Blot is a widely used application for these antibodies. ELISA and Immunohistochemistry are also common applications.