Anti-MPO antibodies are used in the immunodetection of the protein myeloperoxidase. In humans, the canonical protein has a reported length of 745 amino acid residues and a mass of 83.9 kDa. Its subcellular localization is in the lysosomes. Up to 3 different isoforms have been reported for this protein. It is notably expressed in the bone marrow. A member of the Peroxidase protein family, MPO is known to be a part of the host defense system of polymorphonuclear leukocytes. Post-translational modifications have been described, including glycosylation. The MPO marker can be used to identify Granulocyte-Macrophages Progenitor Cells (GMP), Promyelocytes, Granulocytes, Neutrophils, and Eosinophils.* MPO gene orthologs have been reported in the mouse, rat, bovine and chimpanzee species. Over 780 citations in the literature describe the use of MPO antibodies in research. ELISA is a widely used application for these antibodies. In addition, Western Blot is also a common application.
*HuBMAP Human Reference Atlas v1.4