Anti-CD83 antibodies are used in the immunodetection of the protein CD83 molecule. In humans, the canonical protein has a reported length of 205 amino acid residues and a mass of 23 kDa. Its subcellular localization is in the membrane. It is noted to be expressed by activated lymphocytes, Langerhans cells and interdigitating reticulum cells. CD83 is believed to play a significant role in antigen presentation or the cellular interactions that follow lymphocyte activation. Post-translational modifications have been described, including glycosylation. The CD83 marker can be used to identify Centrocytes and Dendritic Cells.* Synonyms for this target antigen include HB15, CD83 antigen, B-cell activation protein, CD83 antigen (activated B lymphocytes, immunoglobulin superfamily), cell surface protein HB15, and BL11. CD83 gene orthologs have been reported in the mouse, rat, bovine, chimpanzee and chicken species.
*HuBMAP Human Reference Atlas v1.4