Anti-ITGA2B antibodies are used in the immunodetection of the protein integrin subunit alpha 2b. In humans, the canonical protein has a reported length of 1039 amino acid residues and a mass of 113.4 kDa. Its subcellular localization is in the membrane. Up to 3 different isoforms have been reported for this protein. It is notably expressed in the bone marrow and placenta. A member of the Integrin alpha chain protein family, ITGA2B is known to be involved with angiogenesis and cell adhesion. Post-translational modifications have been described, including glycosylation.
The ITGA2B marker can be used to identify Megakaryocytes (MK) and Lung Megakaryocytes.* Synonyms for this target antigen include BDPLT2, CD41, CD41B, GP2B, GPIIb, GT, GT1, and BDPLT16. ITGA2B gene orthologs have been reported in the mouse, rat, bovine, chimpanzee and chicken species. Over 1600 citations in the literature describe the use of ITGA2B antibodies in research. These antibodies are most commonly used in Flow Cytometry experiments, among other applications.
*HuBMAP Human Reference Atlas v1.4