Fig 1: MK and platelet morphology in LMAN1-deficient mice.(A and B) LMAN1-deficient mice exhibit (A) normal platelet size and morphology by peripheral smear evaluation and (B) normal platelet dense and alpha granule morphology by transmission electron microscopy (TEM). (C) BM histology demonstrates no difference in MK morphology between both genotypes. (D) Percentages and (E) numbers of BM MK progenitors (Lin–Sca–KIT+CD150+CD41+) in LMAN1-deficient compared with littermate control mice by flow cytometry. Data were analyzed using unpaired Student’s t test.