Anti-GATA3 antibodies are used in the immunodetection of the protein GATA binding protein 3. In humans, the canonical protein has a reported length of 443 amino acid residues and a mass of 47.9 kDa. Its subcellular localization is in the nucleus. Up to 2 different isoforms have been reported for this protein. It is notably expressed in many tissues, such as the breast and kidney. GATA3 is reported to be a transcriptional activator, which binds to the enhancer of the T-cell receptor alpha and delta genes. The GATA3 marker can be used to identify Midbrain Splatter Neurons, Thalamus Splatter Neurons, Brain Splatter Neurons, Connecting Tubule Cells, and Collecting Duct Cells.* Synonyms for this target antigen include HDRS, trans-acting T-cell-specific transcription factor GATA-3, GATA-binding factor 3, and HDR. GATA3 gene orthologs have been reported in the mouse, rat, bovine, frog, zebrafish, chimpanzee and chicken species.
*HuBMAP Human Reference Atlas v1.4