Anti-FLT4 antibodies are used in the immunodetection of the protein fms related receptor tyrosine kinase 4. In humans, the canonical protein has a reported length of 1363 amino acid residues and a mass of 152.8 kDa. Its subcellular localization is in the cell membrane, nucleus, and cytoplasm. Up to 3 different isoforms have been reported for this protein. It is notably expressed in endothelial cells. A member of the Tyr protein kinase protein family, FLT4 is reported to be a tyrosine-protein kinase that acts as a cell-surface receptor for VEGFC and VEGFD, and plays an essential role in adult lymphangiogenesis and in the development of the vascular network and the cardiovascular system during embryonic development. Post-translational modifications have been described, including phosphorylation and glycosylation.
The FLT4 marker can be used to identify Lymphatic Endothelial Cells.* Synonyms for this target antigen include FLT41, LMPH1A, LMPHM1, PCL, VEGFR-3, VEGFR3, vascular endothelial growth factor receptor 3, and CHTD7. FLT4 gene orthologs have been reported in the mouse, rat, bovine, zebrafish, chimpanzee and chicken species.
*HuBMAP Human Reference Atlas v1.4