Anti-CD8B antibodies are used in the immunodetection of the protein CD8 subunit beta. In humans, the canonical protein has a reported length of 210 amino acid residues and a mass of 23.7 kDa. Its subcellular localization is in the cell membrane. Up to 8 different isoforms have been reported for this protein. It is notably expressed in the tonsil, thymus, spleen, lymph node, and appendix. CD8B is known to be involved with adaptive immune responses. Post-translational modifications have been described, including glycosylation, palmitoylation and phosphorylation. The CD8B marker can be used to identify Naive Thymus-Derived CD8+ ?ß T Cells, Double-Positive ?ß Thymocytes, Mature CD8 Single-Positive Thymocytes, and CD8+ ?ß Memory T Cells.* Synonyms for this target antigen include CD8beta, LEU2, LY3, LYT3, Ly-3, P37, T-cell surface glycoprotein CD8 beta chain, and CD8B1. CD8B gene orthologs have been reported in the mouse, rat, bovine, frog, chimpanzee and chicken species.
*HuBMAP Human Reference Atlas v1.4