Anti-Enhancer of zeste 2 polycomb repressive complex 2 subunit antibodies are directed against the protein encoded by the gene EZH2 in humans. The gene may also be known as KMT6, ENX-1, ENX1, EZH2b, histone-lysine N-methyltransferase EZH2, and enhancer of zeste homolog 2. Structurally, the protein is reported to be 85.4 kilodaltons in mass. Based on gene name, canine, porcine, monkey, mouse and rat orthologs may also be found.