Anti-CD40 molecule antibodies are used for the immunodetection of the protein encoded by the CD40 gene. In humans, the canonical protein has a reported length of 277 amino acid residues and a mass of 30.6 kDa. Its subcellular localization is in the cell membrane and is secreted. Alternative splicing is reported to yield 2 different isoforms for this protein. It is a known receptor for TNFSF5/CD40LG. Post-translational modifications have been described, including glycosylation.
The CD40 molecule marker can be used to characterize Naive B Cells and Dendritic Cells.* Other names for this target antigen include CDW40, TNFRSF5, p50, tumor necrosis factor receptor superfamily member 5, B cell surface antigen CD40, and Bp50. Gene orthologs have been identified in the mouse, rat, bovine, frog, chimpanzee and chicken species. Over 700 citations in the literature describe the use of CD40 molecule antibodies in research. Flow Cytometry is a widely used application for these antibodies. In addition, ELISA is also a common application.
*HuBMAP Human Reference Atlas v1.4