Anti-POLR2A antibodies are used in the immunodetection of the protein RNA polymerase II subunit A. In humans, the canonical protein has a reported length of 1970 amino acid residues and a mass of 217.2 kDa. Its subcellular localization is in the nucleus and cytoplasm. Up to 2 different isoforms have been reported for this protein. A member of the RNA polymerase beta' chain protein family, POLR2A is known to be involved with transcription by RNA polymerase II. Post-translational modifications have been described, including methylation, ubiquitination, acetylation and phosphorylation. Synonyms for this target antigen include POLR2, POLRA, RPB1, RPBh1, RPO2, RPOL2, RpIILS, and NEDHIB. POLR2A gene orthologs have been reported in the mouse, rat, bovine, frog, zebrafish, chimpanzee and chicken species. Over 610 citations in the literature describe the use of POLR2A antibodies in research. Western Blot is a widely used application for these antibodies. Immunofluorescence and Immunohistochemistry are also common applications.