Anti-F2R antibodies are used in the immunodetection of the protein coagulation factor II thrombin receptor. In humans, the canonical protein has a reported length of 425 amino acid residues and a mass of 47.4 kDa. Its subcellular localization is in the cell membrane. It is notably expressed in many tissues, such as the colon, testis, and bone marrow. A member of the G-protein coupled receptor 1 protein family, F2R is a high affinity receptor for activated thrombin coupled to G proteins that stimulate phosphoinositide hydrolysis. Synonyms for this target antigen include HTR, PAR-1, PAR1, TR, proteinase-activated receptor 1, protease-activated receptor 1, and CF2R. F2R gene orthologs have been reported in the mouse, rat, bovine, frog, chimpanzee and chicken species. Over 90 citations in the literature describe the use of F2R antibodies in research. Western Blot is a widely used application for these antibodies. ELISA and Immunohistochemistry are also common applications.