Anti-SYP antibodies are used in the immunodetection of the protein synaptophysin. In humans, the canonical protein has a reported length of 313 amino acid residues and a mass of 33.8 kDa. Its subcellular localization is in the cytoplasmic vesicles. Up to 2 different isoforms have been reported for this protein. It is notably expressed in many tissues, such as the cerebellum and cerebral cortex. A member of the Synaptophysin/synaptobrevin protein family, SYP is known to be involved with endocytosis. Post-translational modifications have been described, including glycosylation, ubiquitination and phosphorylation. The SYP marker can be used to identify Neuroendocrine Cells, Merkel Cells, Pancreatic Ductal Cells, and Pancreatic Endocrine Cells.* Synonyms for this target antigen include MRXSYP, XLID96, major synaptic vesicle protein P38, and MRX96. SYP gene orthologs have been reported in the mouse, rat, bovine, frog, zebrafish and chimpanzee species.
*HuBMAP Human Reference Atlas v1.4