Anti-p53 antibodies are essential reagents in flow cytometry for detecting the target protein, tumor protein p53 (TP53). p53 functions as a tumor suppressor in many tumor types, inducing growth arrest or apoptosis depending on the physiological circumstances and cell type. A trans-activator, p53 acts to negatively regulate cell division by controlling a set of genes involved in cell cycle regulation. The p53 protein has intracellular localization and is reported to have at least 12 isoforms. Examine the supplier's provided validation data when comparing p53 antibodies for flow cytometry. Also look for application-specific recommendations, such as dilutions, protocols, sample types, and other helpful usage notes.