Anti-ACE2 antibodies are essential reagents in flow cytometry for detecting the target protein, angiotensin converting enzyme 2. ACE2 is carboxypeptidase that plays a central role in cardiovascular homeostasis. Among its functions, it converts angiotensin I to angiotensin 1-9 and angiotensin II to angiotensin 1-7. It is known to act as a receptor for human coronaviruses SARS-CoV and SARS-CoV-2. The protein is embedded in the cell membrane, but can also be secreted upon processing. Up to 2 different isoforms have been reported for this protein. It is reported to be expressed in endothelial cells from small and large arteries, and in arterial smooth muscle cells. When choosing ACE2 flow cytometry antibodies, examine the supplier's provided validation data. Also look for application-specific recommendations, such as dilutions, protocols, sample types, and other helpful usage notes.