Mouse ACE-2 Antibody AF3437 from R&D Systems, a Bio-Techne Brand

Product Specs
ItemMouse ACE-2 Antibody
CompanyR&D Systems, a Bio-Techne Brand
Price $499.00Supplier Page View Company Product Page
Catalog NumberAF3437
Quantity100 ug (also 25 ug)
ApplicationsFlow Cytometry,ELISA,Immunohistochemistry,Immunoprecipitation,Western Blot,Immunohistochemistry-Frozen,Simple Western
FormatLyophilized from a 0.2 µm filtered solution in PBS with Trehalose. *Small pack size (SP) is supplied either lyophilized or as a 0.2 µm filtered solution in PBS
Conjugate/TagUnconjugated
ConcentrationLYOPH
PurityAntigen Affinity-purified
ReactivityMouse,Rat,Transgenic Mouse
TargetACE-2
HostGoat
IsotypeIgG
Antibody TypePrimary Antibodies
NCBI Gene Aliases2010305L05Rik
NCBI Full Gene Nameangiotensin I converting enzyme (peptidyl-dipeptidase A) 2
ClonalityPolyclonal
ImmunogenChinese hamster ovary cell line CHO-derived recombinant mouse ACE-2, Gln18-Thr740, Accession # Q8R0I0
StorageUse a manual defrost freezer and avoid repeated freeze-thaw cycles. 12 months from date of receipt, -20 to -70 °C as supplied. 1 month, 2 to 8 °C under sterile conditions after reconstitution. 6 months, -20 to -70 °C under sterile conditions after reconstitution

Specifications/Features

Available conjugates: Unconjugated

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R&D Systems, a Bio-Techne Brand

614 McKinley Place N.E.

Minneapolis, Minnesota 55413

United States

Phone: 1 (800) 343-7475
1 (612) 379-2956

Fax: 1 (612) 656-4400

Company Profile

Website: http://www.rndsystems.com

(1) A comprehensive molecular atlas of the mesenchymal cell types in the mouse liverEMBO ReportsSeptember 15, 2025Riikka Pietilä, Guillem Genové, Giuseppe Mocci, Yuyang Miao, Jianping Liu, Stefanos Leptidis, Francesca Del Gaudio, Martin Uhrbom, Elisa Vázquez-Liébanas, Sonja Gustafsson, et al.Aix-Marseille University, France)",Gja5 tm1Lumi Antibodies,Antibodies,Antibodies ACE2 (goat),R&D Systems,AF3437 Alpha-SMA-Cy3 (mouse),Sigma,C6198 Alpha-SMA-FITC (mouse),Sigma,F3777 CD200 (goat),R&D Systems,AF2724 CD31

(2) A humanised ACE2, TMPRSS2, and FCGRT mouse model reveals the protective efficacy of anti-receptor binding domain antibodies elicited by SARS-CoV-2 hybrid immunityEBioMedicineMarch 1, 2025Ana-Sosa-Batiz F, Verma SK, Shafee N, Miller R, Conner C, Hastie KM, Timis J, Maule E, Nguyen MN, Tran L, et al.sc-515727), hFcRn (Santa Cruz Biotechnology, sc-271745), mGAPDH (Cell Signalling, 14C10), mACE2 (R&D Systems, AF3437), mTMPRSS2 (Santa Cruz Biotechnology, sc-515727), and mFcRn (R&D Systems, AF6776). Membranes were then

(3) IL-1β-driven NF-κB transcription of ACE2 as a Mechanism of Macrophage Infection by SARS-CoV-2bioRxiv : the preprint server for biologyFebruary 13, 2025Lee C, Khan R, Mantsounga CS, Sharma S, Pierce J, Amelotte E, Butler CA, Farinha A, Parry C, Caballero O, et al.directed against human ACE2 (0.4 μg/mL; R&D Systems, MAB10823) or Mouse ACE2 (0.25 μg/mL; R&D Systems, AF3437) or a species nonspecific ACE2 antibody (0.4 μg/mL; R&D Systems, AF933). Secondary antibodies included

(4) Involvement of metformin and aging in salivary expression of ACE2 and TMPRSS2BioFactors (Oxford, England)January 1, 2025Shikama Y, Otsuka K, Shikama Y, Furukawa M, Ishimaru N, Matsushita K.(Bio‐Rad, Hercules, CA, USA). Membranes were incubated with antibodies against ACE2 (for tissue lysates: AF3437, for saliva: AF933, R&D Systems, Minneapolis, MN, USA), α‐amylase (A8273, Sigma‐Aldrich, St. Louis,

(5) Enteroendocrine Cells Protect the Stem Cell Niche by Regulating Crypt Metabolism in Response to NutrientsCellular and molecular gastroenterology and hepatologyJanuary 1, 2023McCauley HA, Riedman AM, Enriquez JR, Zhang X, Watanabe-Chailland M, Sanchez JG, Kechele DO, Paul EF, Riley K, Burger C, et al.Antibody,Company,Catalog #,Host,Dilution Angiotensin Converting Enzyme 2 (Ace2),R&D Systems,AF3437,Goat,1:200 Chromogranin A,ImmunoStar,20085,Rabbit,1:200 Carbonic anhydrase 4,R&D Systems,AF2414,Goat,1:200 Ki67,Cell

(6) A dietary change to a high-fat diet initiates a rapid adaptation of the intestineCell reportsNovember 15, 2022Enriquez JR, McCauley HA, Zhang KX, Sanchez JG, Kalin GT, Lang RA, Wells JM.Ecadherin (Cdh11),R&D Systems,Cat# MAB7481; RRID: AB_2076679 Goat polyclonal Ace-2,R&D Systems,Cat# AF3437 RRID: AB_223140 Rabbit polyclonal Lysozyme,Dako,Cat# A0099 RRID: AB_2341230 Rabbit polyclonal SP-1

(7) Gut microbiota-derived metabolites confer protection against SARS-CoV-2 infectionGut microbesJanuary 1, 2022Brown JA, Sanidad KZ, Lucotti S, Lieber CM, Cox RM, Ananthanarayanan A, Basu S, Chen J, Shan M, Amir M, et al.in PBS for 60 min at room temperature, then incubated with goat anti-mouse ACE2 (1:200; R&D Systems AF3437) at 4°C overnight. After a wash step, sections were incubated with donkey anti-goat IgG H&L Alexa Fluor 488

(8) SARS-CoV-2 deregulates the vascular and immune functions of brain pericytes via Spike proteinNeurobiology of diseaseDecember 1, 2021Khaddaj-Mallat R, Aldib N, Bernard M, Paquette AS, Ferreira A, Lecordier S, Saghatelyan A, Flamand L, ElAli A.primary antibodies were used; rabbit anti-PDGFRβ (Abcam; ab32570; 1/250), goat anti-ACE2 (R&D systems; AF3437; 1/200), rabbit anti-fibronectin (Abcam; ab18723; 1/250), and rabbit anti-desmin (Abcam; ab15200; 1/500).

(9) Chitinase 3-like-1 is a therapeutic target that mediates the effects of aging in COVID-19JCI insightNovember 8, 2021Kamle S, Ma B, He CH, Akosman B, Zhou Y, Lee CM, El-Deiry WS, Huntington K, Liang O, Machan JT, et al.at room temperature. The sections were then incubated with primary antibodies — α-Ace2 (R&D Systems, AF3437), α-Tmprss2 (Abcam, ab92323), α-Ctsl (R&D Systems, AF1515), α-CC10 (Santa Cruz Biotechnology, sc-365992),

(10) E-cigarette vape and lung ACE2 expression: Implications for coronavirus vulnerabilityEnvironmental toxicology and pharmacologyAugust 1, 2021Lallai V, Manca L, Fowler CD.min. Sections were next incubated overnight at 4 °C in primary antibody (goat anti-mACE2, 1:100; Cat # AF3437; R&D Systems) in blocking solution. Thereafter, sections were washed 0.1 M PBS containing 0.5 % Triton

(11) Mice with induced pulmonary morbidities display severe lung inflammation and mortality following exposure to SARS-CoV-2JCI insightJune 22, 2021Falach R, Bar-On L, Lazar S, Kadar T, Mazor O, Aftalion M, Gur D, Evgy Y, Shifman O, Aminov T, et al.ACE2 receptor staining, cells were stained using goat anti-mACE2 antibody (R&D Systems, Bio-Techne, AF3437) followed by donkey anti-goat IgG coupled to AF647 (Thermo Fisher Scientific, A20186). For TMPRSS2 staining,

(12) Expression of the ACE2 virus entry protein in the nervus terminalis reveals the potential for an alternative route to brain infection in COVID-19bioRxiv : the preprint server for biologyJune 7, 2021Bilinska K, von Bartheld CS, Butowt R.Membranes were blocked with 5% dry milk (Bio-Rad), incubated with goat polyclonal anti-ACE2 (R&D Systems AF3437) at 1/1000 or rabbit polyclonal anti-GAPDH (Protein-Tech, #10494–1-AP) at 1/5000 dilution overnight

(13) Male bias in ACE2 basic science research: missed opportunity for discovery in the time of COVID-19American journal of physiology. Regulatory, integrative and comparative physiologyJune 1, 2021Miličić Stanić B, Maddox S, de Souza AMA, Wu X, Mehranfard D, Ji H, Speth RC, Sandberg K.of six different sources of ACE2 antibodies including: R&D Systems anti-mouse polyclonal (Cat. No. AF3437) at 0.4 mg/mL; Abcam (Cambridge, MA) anti-mouse monoclonal (Cat. No. ab108252) at 1:1,000 dilution;

(14) Sex differences in the induction of angiotensin converting enzyme 2 (ACE-2) in mouse lungs after e-cigarette vapor exposure and its relevance to COVID-19Journal of investigative medicine : the official publication of the American Federation for Clinical ResearchJune 1, 2021Naidu V, Zeki AA, Sharma P.followed by blocking with 3% bovine serum albumin, and then incubated with ACE-2 antibody (1:1000, #AF3437; R&D Systems, USA) overnight at 4°C, followed by washing and incubation with secondary antibody (1:5000).

(15) A cellular and spatial map of the choroid plexus across brain ventricles and agesCellMay 27, 2021Dani N, Herbst RH, McCabe C, Green GS, Kaiser K, Head JP, Cui J, Shipley FB, Jang A, Dionne D, et al.anti-5-HT (1:3000, S5545, Sigma), Mouse anti-AQP1 (1:100, sc-32737, Santa Cruz), Goat anti-ACE2 (1:250, AF3437, R&D Systems), Mouse anti-ACTA2-Cy3 (1:200, C6198, Sigma); Rabbit anti-CCDC67 (1:500, 24579-1-AP, Proteintech),

(16) Chitinase 3-like-1 is a Therapeutic Target That Mediates the Effects of Aging in COVID-19bioRxiv : the preprint server for biologyFebruary 16, 2021Kamle S, Ma B, He CH, Akosman B, Zhou Y, Lee CM, El-Deiry WS, Huntington K, Liang O, Machan JT, et al.

(17) Oxygen conditions oscillating between hypoxia and hyperoxia induce different effects in the pulmonary endothelium compared to constant oxygen conditionsPhysiological reportsFebruary 1, 2021Wohlrab P, Johann Danhofer M, Schaubmayr W, Tiboldi A, Krenn K, Markstaller K, Ullrich R, Ulrich Klein K, Tretter V.were detected by primary anti‐ACE/CD143 (R&D Systems cat.nr. AF1513), anti‐ACE2 (R&D Systems cat.nr.AF3437), anti‐eNOS (Cell Signaling Technology cat.nr. 9,586), anti‐ß‐Actin (Cell Signaling Technology cat.nr.

(18) Expression of the ACE2 Virus Entry Protein in the Nervus Terminalis Reveals the Potential for an Alternative Route to Brain Infection in COVID-19Frontiers in cellular neuroscienceJanuary 1, 2021Bilinska K, von Bartheld CS, Butowt R.Membranes were blocked with 5% dry milk (Bio-Rad), incubated with goat polyclonal anti-ACE2 (R&D Systems AF3437) at 1/1,000 or rabbit polyclonal anti-GAPDH (Protein-Tech, #10494-1-AP) at 1/5,000 dilution overnight

(19) Expression of the SARS-CoV-2 Entry Proteins, ACE2 and TMPRSS2, in Cells of the Olfactory Epithelium: Identification of Cell Types and Trends with AgeACS chemical neuroscienceJune 3, 2020Bilinska K, Jakubowska P, Von Bartheld CS, Butowt R.blocked with 5% dry milk (Bio-Rad), incubated with anti-ACE2 (Proteintech #21115-1-AP or R&D Systems, #AF3437) at 1/1000 or anti-GAPDH (Proteintech #10494-1-AP) at 1/5000 dilution rabbit polyclonal antibodies overnight

(20) Novel Variants of Angiotensin Converting Enzyme-2 of Shorter Molecular Size to Target the Kidney Renin Angiotensin SystemBiomoleculesDecember 17, 2019Wysocki J, Schulze A, Batlle D.containing 0.1% Tween 20. The nitrocellulose membranes were incubated with primary anti-ACE2 antibody [AF3437 (R&D Systems, Minneapolis, MN, USA) or Ab38888 (Abcam, Cambridge, MA, USA)] and horseradish peroxidase-conjugated

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Mouse ACE-2 Antibody

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ACE-2 Antibody

ACE-2 Antibody

ACE-2 Antibody

Mouse ACE-2 Antibody from R&D Systems, a Bio-Techne Brand

Specifications/Features

R&D Systems, a Bio-Techne Brand

Citations (23)

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Mouse ACE-2 Antibody from R&D Systems, a Bio-Techne Brand

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