Fig 1: LPS-induced proteomic alterations of PFC synapses reflect signaling, cytoskeletal, and metabolic changes. (A) Volcano plot shows significantly altered protein spots from PFC synaptosome samples (red – increased, blue – decreased) with labels of identified proteins (FC: fold change). (B) Pie chart shows the functional groups of identified proteins. (C) Clustered PPI network of altered proteins in response to LPS treatment. Nodes are colored based on FC, and their size represent eigenvector centrality (EC). (D) Top 3 enriched GO biological process terms for Cluster1, 2, 4, and 6. The number of related genes correlates with circle sizes, adjusted P-value is represented by color scales. (E) The PPI network of altered proteins linked to IL-1 signaling pathway. Nodes are colored based on FC, and their size represent EC. (F) Scatter plot of node degree and eigenvector of the linked PPI network. Pearson’s correlation analysis and ANOVA test were performed, proteins with outstanding centrality index are labeled. (For interpretation of the references to color in this figure legend, the reader is referred to the Web version of this article.)