Anti-IL2RA antibodies are used in the immunodetection of the protein interleukin 2 receptor subunit alpha. In humans, the canonical protein has a reported length of 272 amino acid residues and a mass of 30.8 kDa. Its subcellular localization is in the membrane. It is notably expressed in the tonsil, spleen, lymph node, and cerebellum. IL2RA is a known receptor for interleukin-2. Post-translational modifications have been described, including glycosylation. The IL2RA marker can be used to identify Large Intestine Lamina Propria Lymphocytes, T Follicular Regulatory Cells, Regulatory T Cells, and T Regulatory Cells.* Synonyms for this target antigen include IDDM10, IL2R, IMD41, TCGFR, p55, IL-2 receptor subunit alpha, IL-2R subunit alpha, and CD25. IL2RA gene orthologs have been reported in the mouse, rat, bovine, chimpanzee and chicken species.
*HuBMAP Human Reference Atlas v1.4