The Biocompare Cells and Microorganisms search tool is a diverse catalog of primary cells, cell lines, and microbial strains from many suppliers. Cell lines include stable immortalized lines, cells overexpressing target genes, hybridomas, reporter cell lines, and knockout cells. It features cells from various lineages, including myeloid and lymphoid cells, neuronal cells, fibroblasts, endothelial cells, hepatocytes, myocytes, and more. Users can also search for specific cells based on tissue type or host species, providing flexibility for a wide array of research applications. Important considerations when choosing cells for research include cell line authentication, culturing requirements, genetic or phenotypic modifications, and the intended downstream application. Inspect the product datasheets from the cell supplier pages for more detailed information.
The CHO cell line is originally derived from the Chinese hamster ovary, and has become a staple source of cells due to their robust growth as adherent cells or in suspension. They are amenable to genetic modifications and methods for cell transfection, recombinant protein expression, and clone selection are well characterized. CHO cells can also undergo human-compatible post-translational modifications, making them ideal for therapeutic and pharmaceutical applications like protein manufacturing. CHO cells lack proline synthesis abilities and do not express EGFR. Various variant cell lines have emerged from CHO, such as CHO-K1 which lack dihydrofolate reductase (DHFR) activity.