NFE2L2 ELISA kits are immunoassay tools for the measurement of the protein NFE2 like bZIP transcription factor 2, which is encoded by the NFE2L2 gene in humans. Functionally, this protein is reported to be a transcription factor that plays a key role in the response to oxidative stress: binds to antioxidant response (ARE) elements present in the promoter region of many cytoprotective genes, such as phase 2 detoxifying enzymes, and promotes their expression, thereby neutralizing reactive electrophiles. The canonical protein structure is reported to have an amino acid length of 605 residues, a mass of 67.8 kDa, and is a member of the BZIP protein family. It is known to be localized in the nucleus and cytoplasm and is widely expressed across many tissue types. As many as 3 protein isoforms have been reported. The protein has been noted to be post-translationally glycosylated, ubiquitinated, acetylated and phosphorylated. The NFE2L2 gene has been associated with the disease, Immunodeficiency, developmental delay, and hypohomocysteinemia. Other alias names for this target include IMDDHH, NRF2, Nrf-2, nuclear factor erythroid 2-related factor 2, nuclear factor erythroid-derived 2-like 2, and HEBP1.
The detection range for different NFE2L2 ELISA kits can vary, with some assays measuring target concentrations as low as 1.22 pg/mL and as high as 60 ng/mL. Click on the products below for more detailed ELISA kit information, such as target reactivity and assay sensitivity.