The following fms related receptor tyrosine kinase 3 ELISA kits are useful research tools for the measurement of fms related receptor tyrosine kinase 3 in biological samples. In humans this protein is encoded by the FLT3 gene. This protein is reported to be a tyrosine-protein kinase that acts as cell-surface receptor for the cytokine FLT3LG and regulates differentiation, proliferation and survival of hematopoietic progenitor cells and of dendritic cells. The canonical protein structure is reported to have an amino acid length of 993 residues, a mass of 112.9 kDa, and is a member of the Tyr protein kinase protein family. Its subcellular location is known to be in the ER and membrane. In addition, it is notably expressed in bone marrow, in hematopoietic stem cells, in myeloid progenitor cells and in granulocyte/macrophage progenitor cells. As many as 2 protein isoforms have been reported. In certain instances, it is also post-translationally N-glycosylated, ubiquitinated and phosphorylated. The gene encoding this protein has been associated with the disease, Leukemia. This protein may also be known as FLK-2, FLK2, STK1, receptor-type tyrosine-protein kinase FLT3, CD135 antigen, and CD135.
The detection range for different fms related receptor tyrosine kinase 3 ELISA kits can vary, with some assays measuring target concentrations as low as 31.25 pg/mL and as high as 60 ng/mL. Use the search filters to narrow your search and click on the ELISA kits below for more detailed information, such as reactivity and assay sensitivity.