Anti-RXRA antibodies are used in the immunodetection of the protein retinoid X receptor alpha. In humans, the canonical protein has a reported length of 462 amino acid residues and a mass of 50.8 kDa. Its subcellular localization is in the nucleus, mitochondria, and cytoplasm. Up to 2 different isoforms have been reported for this protein. It is reported to be expressed in the lung fibroblasts. A member of the Nuclear hormone receptor protein family, RXRA is a known receptor for retinoic acid that acts as a transcription factor. Post-translational modifications have been described, including sumoylation, acetylation and phosphorylation.
The RXRA marker can be used to identify Placental Microvascular Endothelial Cells.* Synonyms for this target antigen include RXR-alpha, RXRalpha, retinoic acid receptor RXR-alpha, nuclear receptor subfamily 2 group B member 1, retinoid X nuclear receptor alpha, and NR2B1. RXRA gene orthologs have been reported in the mouse, rat, bovine, frog, chimpanzee and chicken species.
*HuBMAP Human Reference Atlas v1.4