Anti-ARC antibodies are used in the immunodetection of the protein activity regulated cytoskeleton associated protein. In humans, the canonical protein has a reported length of 396 amino acid residues and a mass of 45.3 kDa. A member of the ARC/ARG3.1 protein family, Arc is a reported master regulator of synaptic plasticity that self-assembles into virion-like capsids that encapsulate RNAs and mediate intercellular RNA transfer in the nervous system. Post-translational modifications have been described, including ubiquitination, palmitoylation and phosphorylation. Arc is also used as a cellular marker for characterizing neuronal cells. Synonyms for this target antigen include hArc, ARC/ARG3.1, activity-regulated gene 3.1 protein homolog, and Arg3.1. ARC gene orthologs have been reported in the mouse, rat, bovine, frog, chimpanzee and chicken species.