Arc Antibody 156 005 from Synaptic Systems GmbH

Product Specs
ItemArc Antibody
CompanySynaptic Systems GmbH
Price $465.00Supplier Page View Company Product Page
Catalog Number156 005
Quantity100 µl
Reactivityrat, mouse
ApplicationsWB, ICC, IHC
Conjugate/Tagunconjugated
NCBI Gene AliasesArc3.1, arg3.1, mArc
TargetArc
HostGuinea pig
Clonalitypolyclonal
ImmunogenRecombinant protein corresponding to AA 1 to 396 from mouse Arc
Purityaffinity purified
NCBI Full Gene Nameactivity regulated cytoskeletal-associated protein
ValidationKO
Antibody TypePrimary antibody
Formatlyophilized

Questions and Answers

Can this antibody be used for immunohistochemistry in mouse brain tissue?

Yes, the Arc antibody has been shown to work effectively in immunohistochemistry applications for mouse brain tissue, as evidenced by its use in studies examining synaptic changes and neuroplasticity in various mouse models (, ).

What specific applications has this antibody been cited in?

The Arc antibody has been cited in applications such as Western blotting, immunocytochemistry, and immunohistochemistry, demonstrating its versatility in studying neuronal activity and synaptic plasticity (, ).

Is this antibody suitable for detecting Arc protein in different mouse models?

Yes, the Arc antibody has been utilized in multiple studies involving different mouse models, including those with genetic modifications affecting synaptic function, confirming its reliability for detecting Arc protein across various experimental contexts (, ).

How has this antibody contributed to understanding neuronal activity in research?

The Arc antibody has been instrumental in studies linking neuronal activity to synaptic changes, such as its role in the transcriptional response of dentate granule neurons during memory encoding, highlighting its importance in neuroplasticity research (, ).

Synaptic Systems GmbH

Rudolf-Wissell-Str. 28

Goettingen 37079

Germany

Phone: +49-551-50556-0
+49-551-50556-384

Company Profile

Website: http://www.sysy.com/

(1) Combinative Protein Expression of Immediate Early Genes c-Fos, Arc, and Npas4 Along Aversive and Appetitive Experience-Related Neural NetworksHippocampusSeptember 1, 2025Arai M, Osanai H, Snell CC, Gawf KE, Kitamura T, Ogawa SK.

(2) Targeted rescue of synaptic plasticity improves cognitive decline in sepsis-associated encephalopathyMolecular TherapyJuly 3, 2024Benedikt Grünewald, Jonathan Wickel, Nina Hahn, Vahid Rahmati, Hanna Rupp, Ha-Yeun Chung, Holger Haselmann, Anja S. Strauss, Lars Schmidl, Nina Hempel, et al.for 30 min. The first antibody was incubated in blocking buffer overnight at 4°C (anti-ARC/Arg3.1 [#156 005], anti-NeuN [#266 004, 1:1,000], anti-GFP [#132 006, 1:500], all Synaptic Systems, Göttingen, Germany;

(3) Neuronal activity-related transcription is blunted in immature compared to mature dentate granule cellsHippocampusApril 1, 2023Parylak SL, Qiu F, Linker SB, Gallina IS, Lim CK, Preciado D, McDonald AH, Zhou X, Gage FH.Chicken anti-GFP (Aves Labs #GFP-1020, RRID:AB_10000240). Guinea pig anti-ARC (Synaptic Systems #156005, RRID:AB_2151848 and #156004, RRID:AB_2619853). Rabbit anti-FOS (Synaptic Systems #226003, RRID:AB_2231974).

(4) CD47 Protects Synapses from Excess Microglia-Mediated Pruning during DevelopmentNeuronOctober 10, 2018Lehrman EK, Wilton DK, Litvina EY, Welsh CA, Chang ST, Frouin A, Walker AJ, Heller MD, Umemori H, Chen C, et al.RRID:AB_321292), 1:200, clone 5C6), TUJ1 (Covance (MMS-435P, RRID:AB_2313773), 1:400), Arc (Synaptic Systems (156-005, RRID:AB_2151848), 1:500), NeuN (Millipore (MAB377, RRID:AB_229877), 1:500), NR-1 (Millipore (05-432,

(5) Class I Histone Deacetylase Inhibition by Tianeptinaline Modulates Neuroplasticity and Enhances MemoryACS chemical neuroscienceSeptember 19, 2018Zhao WN, Ghosh B, Tyler M, Lalonde J, Joseph NF, Kosaric N, Fass DM, Tsai LH, Mazitschek R, Haggarty SJ.h. Cells were ﬁxed, permeabilized, and immunostained for MAP2 (Millipore, AB5543), Arc (Synaptic Systems, #156005), and H3K9ac (Millipore, #07-352). Images were taken on an IN Cell 6000 (GE Healthcare Life Sciences)

(6) A novel environment-evoked transcriptional signature predicts reactivity in single dentate granule neuronsNature communicationsAugust 6, 2018Jaeger BN, Linker SB, Parylak SL, Barron JJ, Gallina IS, Saavedra CD, Fitzpatrick C, Lim CK, Schafer ST, Lacar B, et al.AF647 (Jackson ImmunoResearch #712-605-153, 1:250). Images of IEG expression used guinea pig anti-ARC (#156005, Synaptic Systems, 1:2000) and goat anti-c-FOS (sc-52-G, Santa Cruz, 1:250) primaries and donkey anti-guinea pig

(7) Bidirectional Regulation of Aggression in Mice by Hippocampal Alpha-7 Nicotinic Acetylcholine ReceptorsNeuropsychopharmacologyMay 1, 2018Alan S Lewis, Steven T Pittenger, Yann S Mineur, Dawson Stout, Philip H Smith, Marina R Picciottoas previously described (Lewis et al, 2015). Staining for Arc (guinea pig, 1 : 1000, Synaptic Systems 156005, Goettingen, Germany), CaMKII (mouse, 1 : 1000, Abcam ab22609 [6G9], Cambridge, MA, USA), GABA (rabbit,

(8) Chemogenomic analysis reveals key role for lysine acetylation in regulating Arc stabilityNature communicationsNovember 21, 2017Lalonde J, Reis SA, Sivakumaran S, Holland CS, Wesseling H, Sauld JF, Alural B, Zhao WN, Steen JA, Haggarty SJ.shared by Dr. Grace Gill. Antibodies and pharmacological compounds The antibody recognizing Arc (#156 005, 1:2000 for WB and 1:1000 for IF) was purchased from Synaptic Systems (Goettingen, Germany). The specificity

(9) Activity-Dependent Dysfunction in Visual and Olfactory Sensory Systems in Mouse Models of Down SyndromeThe Journal of NeuroscienceOctober 11, 2017Christopher M. William, Lubna Saqran, Matthew A. Stern, Charles L. Chiang, Scott P. Herrick, Aziz Rangwala, Mark W. Albers, Matthew P. Frosch, Bradley T. Hymanacross 10 slides. Sections were stained by overnight incubation with guinea pig anti-Arc (catalog #156 005, Synaptic Systems; 1:1000), mouse anti-NeuN (MAB377, Millipore; 1:1000), mouse anti-parvalbumin (P3088, Sigma-Aldrich;

(10) Ketamine Corrects Stress-Induced Cognitive Dysfunction through JAK2/STAT3 Signaling in the Orbitofrontal CortexNeuropsychopharmacology : official publication of the American College of NeuropsychopharmacologyMay 1, 2017Patton MS, Lodge DJ, Morilak DA, Girotti M.pJAK2 signal, cells were incubated overnight with guinea pig anti-Arc pAb (1 : 200, Synaptic Systems 156-005), then Alexa-647-conjugated antiguinea pig secondary antibody, followed by DNAseI-Alexa488 (9 μg/ml,

(11) Distinct synaptic and neurochemical changes to the granule cell-CA3 projection in Bassoon mutant miceFrontiers in synaptic neuroscienceJanuary 1, 2015Dieni S, Nestel S, Sibbe M, Frotscher M, Hellwig S.Synaptic Systems), and a guinea pig polyclonal antibody against activity-related cytoskeletal protein (“anti-Arc”; #156005; Synaptic Systems) were used. For labeling of neuropeptides within the MF projection, rabbit polyclonal

(12) Immature doublecortin-positive hippocampal neurons are important for learning but not for rememberingThe Journal of neuroscience : the official journal of the Society for NeuroscienceApril 10, 2013Vukovic J, Borlikova GG, Ruitenberg MJ, Robinson GJ, Sullivan RK, Walker TL, Bartlett PF.

(13) BDNF and its pro-peptide are stored in presynaptic dense core vesicles in brain neuronsThe Journal of cell biologyMarch 19, 2012Dieni S, Matsumoto T, Dekkers M, Rauskolb S, Ionescu MS, Deogracias R, Gundelfinger ED, Kojima M, Nestel S, Frotscher M, et al.and guinea pig polyclonal antibodies against activity-related cytoskeletal protein (anti-Arc/Arg3.1; #156005; Synaptic Systems) were used. A mouse monoclonal antibody against the 130-kD Golgi matrix protein (anti-GM130)

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Arc Antibody

Arc Antibody

Arc Antibody

Arc Antibody from Synaptic Systems GmbH

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Arc Antibody from Synaptic Systems GmbH

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