Anti-GNAS antibodies are used in the immunodetection of the protein GNAS complex locus. In humans, the canonical protein has a reported length of 245 amino acid residues and a mass of 28 kDa. Its subcellular localization is in the cytoplasmic vesicles and is secreted. Up to 8 different isoforms have been reported for this protein. It is a member of the NESP55 protein family. Post-translational modifications have been described, including protein cleavage. The GNAS marker can be used to identify Brain Splatter Neurons.* Synonyms for this target antigen include AHO and C20orf45. GNAS gene orthologs have been reported in the mouse, rat, bovine, frog, zebrafish, chimpanzee and chicken species.
*HuBMAP Human Reference Atlas v1.4