Anti-CD163 antibodies are used in the immunodetection of the protein CD163 molecule. In humans, the canonical protein has a reported length of 1156 amino acid residues and a mass of 125.5 kDa. Its subcellular localization is in the cell membrane and is secreted. Up to 4 different isoforms have been reported for this protein. It is notably expressed in the spleen, skin, lymph node, lung, and bone marrow. Post-translational modifications have been described, including glycosylation, protein cleavage and phosphorylation. The CD163 marker can be used to identify Type 3 Dendritic (DC3) Cells, Large Intestine Macrophages, Macrophages, Alveolar Macrophages CCL3+ Cells, and Alveolar Macrophages.* Synonyms for this target antigen include MM130, SCARI1, scavenger receptor cysteine-rich type 1 protein M130, hemoglobin scavenger receptor, macrophage-associated antigen, and M130. CD163 gene orthologs have been reported in the mouse, rat and chimpanzee species.
*HuBMAP Human Reference Atlas v1.4