Anti-NSD2 antibodies are used in the immunodetection of the protein nuclear receptor binding SET domain protein 2. In humans, the canonical protein has a reported length of 1365 amino acid residues and a mass of 152.3 kDa. Its subcellular localization is in the nucleus. Alternative splicing is reported to yield 7 different isoforms for this protein. It is widely expressed across many tissue types. A member of a the Histone-lysine methyltransferase protein family, NSD2 is reported to be a histone methyltransferase, which specifically dimethylates nucleosomal histone H3 at 'Lys-36' (H3K36me2). Synonyms for this target antigen include KMT3G, MMSET, RAUST, REIIBP, TRX5, WHS, WHSC1, and KMT3F.